Clinical Trial

LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study

Study acronym: LISA-Ven-LUS
Recruiting
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Record status
This record was last updated April 7, 2026 (before its estimated July 30, 2026 completion). Its status may not reflect the trial's current state.
Summary
This prospective, non-randomized, unblinded pilot study evaluates and compares the intrapulmonary distribution of exogenous surfactant in preterm neonates when administered via Less Invasive Surfactant Administration (LISA) versus conventional endotracheal intubation (ETT). Lung ultrasound (LUS) will be utilized to assess the pioneer Surfactant Distribution Homogeneity Index (SDHI) to quantify the evenness and extent of surfactant-induced lung aeration. Secondary objectives include evaluating changes in LUS scores, short-term clinical respiratory outcomes, and feasibility parameters for guiding future larger-scale trials.
Trial Details
NCT Number NCT07514481
Lead Sponsor Hamad General Hospital
Conditions Respiratory Distress Syndrome, Newborn
Enrollment 22 participants
Start Date 2026-01-01
Primary Completion 2026-07-30 (estimated)
Study Completion 2026-07-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-07