Clinical Trial

Enhancing Physical Reserve to Promote Resilience in Physically Frail Older Adults

Study acronym: MRI exercise
Recruiting
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Summary
The goal of this clinical trial is to assess the efficacy of combined aerobic and resistance training in enhancing physical reserve in older adults with physical frailty. Investigator contend that enhanced physical reserve will enable preservation of cognitive and physical function. The main questions aims to answer are: (1) Compared with usual care (i.e., CON), will 3-month aerobic and resistance training (ATRT) improve physical reserve in older adults with physical frailty? (2) Compared with CON, will ATRT lead to changes in the neural network organization? (3) Will improved physical reserve lead to better maintenance of cognitive and physical functioning in spite of presence of white matter hyperintensities (WMH)?
Trial Details
NCT Number NCT07513701
Lead Sponsor The Hong Kong Polytechnic University
Conditions Frailty at Older Adults
Enrollment 224 participants
Start Date 2026-01-19
Primary Completion 2028-12-31 (estimated)
Study Completion 2029-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-07