A Comparative Study on the Safety and Efficacy of the Intra-Articular Injectable Filler ALLOHEAL in Patients With Knee Osteoarthritis

ENDOVISION Co., Ltd. has developed an intra-articular knee injection with sodium polynucleotide, chitosan, and type I collagen as its main components, and aims to demonstrate the non-inferiority of the investigational device, ALLOHEAL, compared with the control device, Conjuran®, when administered intra-articularly to patients with knee osteoarthritis for the purpose of reducing mechanical friction within the joint cavity.

NCT Number	NCT07513415
Lead Sponsor	Endovision Co., Ltd. Collaborators: The Catholic University of Korea, Uijeongbu St. Mary's Hospital, National Health Insurance Service Ilsan Hospital, The Catholic University of Korea, Seoul National University Hospital, Chung-Ang University Gwangmyeong Hospital, Ajou University School of Medicine, Konkuk University Medical Center, Bundang CHA General Hospital, Yonsei University Health System, Severance Hospital
Conditions	Knee Osteoarthritis
Enrollment	286 participants
Start Date	2025-02-04
Primary Completion	2027-06 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2026-04-07