Clinical Effectiveness of Tigecycline for Scrub Typhus.

This multicenter, randomized, open-label clinical trial evaluated the efficacy and tolerability of intravenous tigecycline compared with oral doxycycline in adults hospitalized with scrub typhus. Participants were randomly assigned to receive either intravenous tigecycline or oral doxycycline. The primary efficacy outcome was time to defervescence, and tolerability was assessed based on reported adverse events.

NCT Number	NCT07513103
Lead Sponsor	Jin Soo Lee Collaborators: Korean Center for Disease Control and Prevention
Conditions	Scrub Typhus
Enrollment	27 participants
Start Date	2022-11-19
Primary Completion	2024-12-10 (estimated)
Study Completion	2025-01-05 (estimated)
Updated on ClinicalTrials.gov	2026-08-11