This study was designed to develop and evaluate the effectiveness of a web-based supportive care program for individuals diagnosed with colorectal cancer undergoing cancer treatment. The program's effectiveness is evaluated based on the symptom burden and quality of life experienced by patients during cancer treatment. This randomized controlled trial was conducted with the participation of patients diagnosed with colorectal cancer receiving treatment at the Outpatient Chemotherapy Unit of Koç University Hospital. Participants were divided into two groups: an intervention group and a control group. Patients in the intervention group were provided with access to the web-based 'Sağlıkta Buluşalım (Meet in Health) Supportive Care Program' for 3 months in addition to routine care, while the control group received standard care. Data collection tools included a Descriptive Information Form, Edmonton Symptom Assessment System (ESAS), Functional Assessment of Cancer Therapy-Colorectal (FACT-C), Website Usability Scale, and a Telephone Follow-up Form. Statistical analyses, including Mann-Whitney U, Pearson Chi-Square, Fisher's Exact, and Friedman tests, were planned to compare symptom levels and quality of life scores within and between groups over time.