Observational Cohort Study of Chronic Viral Infection in the Central Nervous System

This research team intends to conduct a real-world cohort study of chronic CNS viral infections represented by PML, to evaluate whether administration of immune checkpoint inhibitors improves long-term outcomes in this patient population.Patients with prior follow-up will be enrolled into a retrospective/prospective ambidirectional cohort, and newly diagnosed patients will be enrolled into a prospective cohort.

NCT Number	NCT07512518
Lead Sponsor	Peking Union Medical College Hospital
Conditions	Progressive Multifocal Leukoencephalopathy, Immune Checkpoint Inhibitors
Enrollment	66 participants
Start Date	2023-02-20
Primary Completion	2030-10-25 (estimated)
Study Completion	2030-10-25 (estimated)
Updated on ClinicalTrials.gov	2026-04-06