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Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Dentistry

StatusEnrolling by Invitation
PhaseNot specified
Started
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Record History

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  1. Start date changed from estimate of Apr 2026 to May 1, 2026
    • Eligibility criteria revised
    v2
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The aim of the research is the laboratory assessment of the content as well as the regenerative and anti-inflammatory potential of autologous exosomes (EXO) from platelet-rich plasma (PRP), as well as their comparison with other autologous products used in intra-articular injections, namely platelet-rich plasma and platelet-rich fibrin (PRF). The material for the research will be obtained from patients of the Temporomandibular Joint Dysfunction Clinic at the University Dental Center in Wrocław with chronic pain of the temporomandibular joints (TMJ) and/or masticatory muscles and/or chronic disturbances in temporomandibular joint mobility, as well as from healthy individuals. In the subsequent stages, the biological material will be analyzed under laboratory conditions to compare the composition and biological properties of PRP, PRF and EXO.
Trial Details
NCT Number NCT07511959
Lead Sponsor Wroclaw Medical University
Conditions
(from sponsor)		 Temporomandibular Disorders (TMD), Muscle Pain, TMJ Pain
Related terms Myalgia, Temporomandibular Joint Disorders
Enrollment 68 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov