The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.

This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention. Participants are randomized 1:1 to preoperative dental screening or no screening. The primary outcome is time to first occurrence of all-cause death, redo-intervention of the index valve, or definite infective endocarditis within 2 years. The study uses registry-based follow-up to ensure complete outcome ascertainment.

NCT Number	NCT07511673
Lead Sponsor	Region Skane
Conditions	Infective Endocarditis (IE), Heart Valve Disease
Enrollment	1,300 participants
Start Date	2026-05-06
Primary Completion	2030-12-01 (estimated)
Study Completion	2036-12-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-19