Perioperative Individually Tailored Psychological Intervention in Breast Cancer Surgery

This randomized controlled trial examined whether a perioperative individually tailored psychological intervention can reduce psychological distress and modulate pro-metastatic molecular processes in breast cancer patients undergoing surgery. Forty women with stage I-III breast cancer were randomized to receive either a 6-week individualized psychological intervention or standard nursing care. Primary outcomes included tumor gene expression profiles associated with adrenergic, inflammatory, and metastatic signaling pathways. Secondary outcomes included psychological distress, stress, and resilience measures assessed across multiple perioperative time points.

NCT Number	NCT07510997
Lead Sponsor	Rabin Medical Center Collaborators: SPARK Israel, ICRF, United States, IMH, Israel, IMS, Israel, ISF, Israel, Tel Aviv University, Israel
Conditions	Breast Cancer
Enrollment	40 participants
Start Date	2018-01-01
Primary Completion	2021-12-31 (estimated)
Study Completion	2022-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-06