Hyperoxia vs Normoxia During Cardiopulmonary Bypass

This single-center randomized controlled pilot trial evaluates the effects of intraoperative hyperoxia compared with normoxia during cardiopulmonary bypass (CPB) in adult patients undergoing elective cardiac surgery. The primary aim is to assess the impact on postoperative renal function. Secondary outcomes include inflammatory markers, cardiovascular and pulmonary complications, resource utilization, and short-term mortality.

NCT Number	NCT07510672
Lead Sponsor	University of Padova
Conditions	AKI, Renal Replacement Therapy, NGAL, Arrythmia, Mechanical Ventilation, Tracheostomy, Mechanical Circulatory Support, ICU Length of Stay +4 more
Enrollment	104 participants
Start Date	2025-07-01
Primary Completion	2025-09-15 (estimated)
Study Completion	2025-10-15 (estimated)
Updated on ClinicalTrials.gov	2026-04-03