Efficacy of Human UC-MSC-derived Exosomes and BM-MSC-derived Exosomes for Atrophic Acne Scar

The goal of this clinical trial is to learn if exosomes from human umbilical cord and bone marrow can improve atrophic acne scars when used after fractional CO₂ laser treatment in adults. The main questions it aims to answer are: * Do exosomes improve acne scars more than standard treatment alone? * Are exosomes safe when used after laser treatment? Researchers will compare one side of the face treated with exosomes to the other side treated with a control solution (hyaluronic acid) to see if exosomes improve scar appearance and skin texture. Participants will: * Receive two sessions of fractional CO₂ laser treatment, 4 weeks apart * Have exosomes applied to one side of the face and a control solution applied to the other side after each treatment * Continue applying the assigned solution at home for 2 days after each session * Attend follow-up visits to assess scar improvement, skin texture, healing time, and side effects Researchers will measure changes in acne scars using clinical scoring systems, skin imaging, and patient satisfaction. Safety will also be monitored by recording any side effects such as redness, swelling, or acne flare. This study may help determine whether exosomes can improve the results of laser treatment for acne scars without increasing side effects

NCT Number	NCT07510295
Lead Sponsor	Ngô Anh Tuấn
Conditions	Atrophic Acne Scars
Enrollment	22 participants
Start Date	2025-01-17
Primary Completion	2025-07-07 (estimated)
Study Completion	2025-07-07 (estimated)
Updated on ClinicalTrials.gov	2026-04-14