Risk Factors Affecting Growth in Thalassemic Children at AUCH

Thalassemia major is a hereditary hemoglobinopathy characterized by ineffective erythropoiesis and severe anemia, necessitating lifelong blood transfusions(1,2). Regular transfusions lead to iron overload, a primary driver of growth retardation in affected children. Iron accumulation in tissues like the pituitary and liver disrupts growth hormone secretion and insulin-like growth factor-1 production.

NCT Number	NCT07509996
Lead Sponsor	Assiut University
Conditions	Thalassemia Majors (Beta-Thalassemia Major)
Enrollment	85 participants
Start Date	2026-04-01
Primary Completion	2027-04-01 (estimated)
Study Completion	2027-05-01 (estimated)
Updated on ClinicalTrials.gov	2026-04-03