Clinical Trial

Decision-making and Optimization of Ventilatory Support for AECOPD Patients

Study acronym: OPTIVENT-COPD
Not Yet Recruiting
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Summary
The goal of this retrospective observational study is to learn about how respiratory support is selected and adjusted in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The main questions it aims to answer are: 1. How are different respiratory support modalities selected for patients with AECOPD in real-world practice? 2. What clinical patterns are associated with escalation, de-escalation, switching, or discontinuation of respiratory support during hospitalization? Researchers will review de-identified hospital records of patients admitted with AECOPD and analyze the dynamic use of respiratory support during hospitalization, including conventional oxygen therapy, high-flow nasal cannula oxygen therapy, non-invasive ventilation, and invasive mechanical ventilation. Participants will not receive any study-assigned intervention. The study will use existing clinical data collected during routine inpatient care and will not change diagnosis, treatment, or follow-up.
Trial Details
NCT Number NCT07508943
Lead Sponsor Sir Run Run Shaw Hospital
Conditions Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Enrollment 1,000 participants
Start Date 2026-03-18
Primary Completion 2029-03-18 (estimated)
Study Completion 2029-03-18 (estimated)
Updated on ClinicalTrials.gov 2026-04-02