Clinical Trial

Comparison of Bone Mineral Density in the Third Trimester Between Women in Singleton and Twin Pregnancies Using Questionnaires and REMS Densitometric Examination

Study acronym: TWINBONE
Recruiting
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Summary
This clinical study aims to monitor and evaluate bone mineral density and fracture risk in women with singleton and twin pregnancies through the combined use of: * two specific questionnaires developed by the Fragility Fracture Observatory (OFF), and * a bone densitometric examination using REMS technology, performed between the 35th and 41st week of gestation. Primary objective: • To identify, in the third trimester of pregnancy (between the 35th and 41st gestational week), any differences in bone mineral density (BMD) between women with singleton pregnancies and women with dichorionic and monochorionic twin pregnancies. Secondary objectives: * Evaluate the relationship between bone mineral density (BMD) values and maternal clinical and historical parameters, such as age, body mass index (BMI), and obstetric and medical history. * Evaluate the association between BMD values and scores obtained from validated questionnaires administered to investigate fracture risk and bone health-related quality of life in women with singleton and twin pregnancies.
Trial Details
NCT Number NCT07508553
Lead Sponsor Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions Osteoporosis, Pregnancy, Twin Pregnancy
Enrollment 100 participants
Start Date 2025-12-23
Primary Completion 2026-12-23 (estimated)
Study Completion 2027-12-23 (estimated)
Updated on ClinicalTrials.gov 2026-04-02