Clinical Trial

A Study to Learn About the Effect of Study Medicine Called PF-08653944 on How Quickly the Stomach Empties Its Content in Healthy Adults With Overweight or Obesity

Active, Not Recruiting Phase 1

Summary

This study looks at how a study medicine called PF-08653944 affects how quickly the stomach empties food after eating. It is being done in adults who are overweight or have obesity. Participants will receive the study medicine for a short period, and doctors will measure how the medicine moves through the stomach and monitor safety. The goal is to better understand how this medicine works in the body and to check for any side effects. The information from this study may help researchers plan future studies of this medicine.

Protocol Amendment History 3 changes

critical Trial status changed: RECRUITING → ACTIVE_NOT_RECRUITING 2026-07-10

notable Enrollment increased: 20 -> 22 participants 2026-07-10

critical Recruitment opened 2026-04-24

Trial Details

NCT Number	NCT07508241
Lead Sponsor	Pfizer
Conditions	Obesity, Overweight and/or Obesity, Overweight, Drug Interaction
Enrollment	22 participants
Start Date	2026-03-31
Primary Completion	2027-01-27 (estimated)
Study Completion	2027-01-27 (estimated)
Updated on ClinicalTrials.gov	2026-07-09