Performance of the Treatment of Periodontitis According to the Bioperio® Protocol

This multicenter, prospective, single-arm observational study evaluated the clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis. The protocol combined professional supra-gingival scaling, oral hygiene instruction and motivation, full-mouth subgingival instrumentation, and-in Stage III/IV cases-adjunctive enamel matrix derivative application in deep pockets.

NCT Number	NCT07507474
Lead Sponsor	University of Pisa
Conditions	Periodontitis
Enrollment	5,000 participants
Start Date	2023-12-05
Primary Completion	2025-07-05 (estimated)
Study Completion	2030-12-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-01