Biological Potentials in Arthroscopic All-inside Semitendinosus Anterior Cruciate Ligament Reconstruction

A randomized, double-blind, prospective single-center clinical trial evaluating the effect of biological augmentation in anterior cruciate ligament (ACL) reconstruction. The study compares standard all-inside semitendinosus ACL reconstruction versus biologically enhanced reconstruction incorporating muscle tissue preservation and autologous bone and fibrin augmentation. The primary aim is to assess whether biological augmentation improves graft healing, integration, and clinical outcomes.

NCT Number	NCT07506304
Lead Sponsor	University Hospital Dubrava Collaborators: Arthrex GmbH
Conditions	Cruciate Ligament Reconstruction, Cruciate Ligament Rupture, Cruciate Ligament Injury
Enrollment	70 participants
Start Date	2026-09-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2032-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-16