The goal of this procedure-based interventional study without drugs or devices is to investigate the molecular mechanisms underlying metabolically unfavorable obesity and related clinical phenotypes, in order to identify non-invasive biomarkers capable of early prediction of metabolic syndrome, type 2 diabetes mellitus, MASLD, and cardiovascular disease in adult participants without known cardiovascular or liver disease.
The main questions it aims to answer are:
* What is the association between epicardial and visceral fat thickness and plasma levels of low-grade inflammatory biomarkers?
* How do these parameters relate to the presence of metabolic syndrome, type 2 diabetes mellitus, MASLD, and subclinical atherosclerosis?
Participants will:
* Undergo a comprehensive clinical evaluation, including demographic, anthropometric, and medical history data;
* Complete non-invasive diagnostic assessments, including 12-lead electrocardiogram, transthoracic echocardiography, liver elastography (FibroScan), and carotid Doppler ultrasound;
* Provide peripheral venous blood samples for biochemical, cellular, and molecular analyses.