Clinical Trial

Ning Shen Dan Xiang Gao Fang for Heart-Kidney Disharmony Insomnia

Not Yet Recruiting Phase 2
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Summary
The goal of this clinical trial is to learn if Ning Shen Dan Xiang paste combined with Ejiao (donkey-hide gelatin) works better than Ning Shen Dan Xiang paste combined with agar (placebo substitute) to treat chronic insomnia of the heart-kidney disharmony type in adults. It will also assess safety. The main question is: \- Does Ning Shen Dan Xiang + Ejiao improve sleep quality more than the placebo version, as shown by the change in Pittsburgh Sleep Quality Index (PSQI) score after 8 weeks? Researchers will compare the two pastes (identical in appearance and taste except for Ejiao) and use published literature data as an additional external control. Participants will: Take 20 g of the assigned paste twice daily (morning and evening) for 8 weeks. Attend clinic visits at baseline, week 4, week 8, and 1 week after stopping (week 9 follow-up). Complete PSQI and ISI questionnaires, keep a daily electronic sleep diary, provide blood/stool samples, and undergo safety monitoring (blood/urine tests, ECG, vital signs, and side effect checks).
Trial Details
NCT Number NCT07504536
Lead Sponsor Shanghai 7th People's Hospital
Collaborators: Shanghai University of Traditional Chinese Medicine, DongE E Jiao Coporation Limited
Conditions Insomnia
Enrollment 60 participants
Start Date 2026-03-15
Primary Completion 2027-03-31 (estimated)
Study Completion 2028-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-01