Hyaluronic Acid vs Mitomycin-C in External Dacryocystorhinostomy

RCT to compare the surgical success in patients undergoing external dacryocystorhinostomy with intraoperative Mitomycin-C (0.4 mg/ml) Vs Hyaluronic acid 1% (1ml) as adjuvant, To compare the complication rates and wound healing patterns in each group, To Compare change in tear MMP-9 levels from preoperative (within 1 week before surgery) to postoperative (6 weeks after surgery) , To compare the comfort levels of patients in each group.

NCT Number	NCT07504250
Lead Sponsor	All India Institute of Medical Sciences, Bhubaneswar
Conditions	Dacryocystitis
Enrollment	36 participants
Start Date	2026-04-01
Primary Completion	2027-10-30 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-31