AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

NCT Number	NCT07503210
Lead Sponsor	Novo Nordisk A/S
Conditions	Obesity
Enrollment	600 participants
Start Date	2026-04-21
Primary Completion	2028-06-06 (estimated)
Study Completion	2028-07-04 (estimated)
Updated on ClinicalTrials.gov	2026-07-09