A Study on the Efficacy of 2% Cholesterol Cream in Atopic Dermatitis

Atopic dermatitis is a common chronic inflammatory skin condition characterized by impaired skin barrier function, leading to increased transepidermal water loss (TEWL), dry skin, and itching. Restoration of the skin barrier is an important component of treatment. Cholesterol is a key lipid in the stratum corneum that plays a role in maintaining skin barrier integrity. This study aims to evaluate the efficacy and safety of 2% cholesterol cream in improving skin barrier function and clinical symptoms in patients with mild to moderate atopic dermatitis aged 7-17 years. Participants will be randomly assigned to receive either 2% cholesterol cream or a placebo (cream base), applied twice daily for 12 weeks. Outcomes will include measurements of transepidermal water loss (TEWL), skin hydration, skin pH, Investigator's Global Assessment (IGA), Eczema Area and Severity Index (EASI), and pruritus numeric rating scale (NRS). The results of this study may support the use of cholesterol-containing topical formulations as a safe and effective treatment option for atopic dermatitis.

NCT Number	NCT07503197
Lead Sponsor	Institute of Dermatology, Thailand
Conditions	Atopic Dermatitis (AD), Cholesterol, Skin Barrier to Water Loss, Skin Allergy, Eczema Atopic Dermatitis, Trans Epidermal Water Loss
Enrollment	30 participants
Start Date	2026-04-01
Primary Completion	2026-12-12 (estimated)
Study Completion	2027-02-14 (estimated)
Updated on ClinicalTrials.gov	2026-05-14