Optimizing Endoscopic and Interventional Treatment for Portal Hypertensive Bleeding

This study aims to evaluate the impact of high-risk factors-such as elevated portal venous pressure, concurrent large extra-luminal vessels, portal vein thrombosis, and prominent portosystemic shunts-on the efficacy of endoscopic therapy. By comparing with interventional treatment, the goal is to optimize the clinical management protocol for esophageal and gastric varices, enhance the therapeutic outcomes of portal hypertension-related esophageal and gastric varices, and improve patient prognosis.

NCT Number	NCT07502729
Lead Sponsor	Shanghai Zhongshan Hospital Collaborators: RenJi Hospital, Shandong Provincial Hospital, Qilu Hospital of Shandong University, Third Affiliated Hospital, Sun Yat-Sen University, Nanfang Hospital, Southern Medical University, The First Affiliated Hospital of Nanchang University, Shanghai East Hospital, Shanghai Changzheng Hospital, Second Military Medical University, The General Hospital of Northern Theater Command
Conditions	Portal Hypertension, Gastroesophageal Varices Hemorrhage, Gastric Varices, Esophageal Varices
Enrollment	1,066 participants
Start Date	2026-03-17
Primary Completion	2026-12-31 (estimated)
Study Completion	2027-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-31