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Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual Treatments

Study acronym: ADEM2
StatusRecruiting
PhasePhase 2/3
Started2026-09-23
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Oct 2027 → Feb 2028
See other at-risk trials from Centre Hospitalier Universitaire de Nice

Amendment history

2026-09-25
Recruitment opened
Primary completion pushed: 2027-10 → 2028-02
Completion pushed: 2027-10 → 2028-02
Randomized study comparing the structural efficacy of methotrexate versus placebo in digital osteoarthritis
Trial Details
NCT Number NCT07501507
Lead Sponsor Centre Hospitalier Universitaire de Nice
Conditions Erosive Hand Osteoarthritis
Enrollment 170 participants
Start Date 2026-09-23
Primary Completion 2028-02 (estimated)
Study Completion 2028-02 (estimated)
Updated on ClinicalTrials.gov 2026-09-24