Clinical Trial

Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolerance in People With Gingivitis

Recruiting
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Record status
This record was last updated March 30, 2026 (before its estimated May 5, 2026 completion). Its status may not reflect the trial's current state.
Summary
This study is a six-week, double-blind, randomized, parallel-group controlled clinical study. The objective of this study is to evaluate the changes to the oral microbiome, inflammatory mediators, gingival health indices and to assess oral tolerance after 4 weeks of twice daily use of differing oral hygiene regimens including mouthwash compared to a control group. A follow-up assessment will be completed 2 weeks after cessation of treatments.
Trial Details
NCT Number NCT07501455
Lead Sponsor Kenvue Brands LLC
Conditions Microbiome, Cytokines, Plaque, Gingivitis, Gingival Bleeding
Enrollment 250 participants
Start Date 2026-02-26
Primary Completion 2026-05-05 (estimated)
Study Completion 2026-05-05 (estimated)
Updated on ClinicalTrials.gov 2026-03-30