Decontamination Methods in the Treatment of Peri-implantitis

The goal of this clinical study is to compare the effectiveness of different methods for decontaminating dental implant surfaces in the treatment of peri-implantitis. The main question it aims to answer is: Which combination of an antiseptic solution and an air-polishing powder is most effective for the non-surgical treatment of peri-implantitis? Researchers will compare three different treatment combinations (Miramistin with sodium bicarbonate, chlorhexidine with erythritol, and Octenisept with glycine) in patients diagnosed with peri-implantitis. Participants will receive the combined treatment at intervals of 7-10 days for one month. The study will assess changes in probing depth, bleeding, and bone loss at 1 and 2.5 months after treatment to determine the most effective and balanced approach for preserving implant surfaces and promoting tissue healing.

NCT Number	NCT07500844
Lead Sponsor	Research Centre for Medical Genetics, Russian Federation
Conditions	Peri-implantitis
Enrollment	64 participants
Start Date	2023-02-01
Primary Completion	2025-11-30 (estimated)
Study Completion	2025-12-11 (estimated)
Updated on ClinicalTrials.gov	2026-04-03