Effect of Early Time-Restricted Eating on Appetite, Appetite-Regulatory Hormones and Energy Intake

This randomised crossover study's primary aim is to investigate the effect of short-term fasting (eTRE) on subjective appetite and appetite-regulatory hormones (i.e., leptin, adiponectin, total glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), total peptide YY (PYY), acylated ghrelin and Insulin). In addition, to examine if the one-day early time-restricted eating influences energy expenditure and ad libitum energy intake in the periods following the standard meal test. The researchers will compare normal eating with early Time-Restricted Eating (eTRE) in healthy men.

NCT Number	NCT07500792
Lead Sponsor	University of Glasgow Collaborators: University of Jazan
Conditions	Healthy Adult Male
Enrollment	12 participants
Start Date	2026-05-01
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-16