Ultrasound Guided Infratemporal Sphenopalatine Ganglion Supravoltage Versus Standard Voltage Pulsed Radiofrequency for Pain Alleviation in Chronic Refractory Migraine.

* PRF performed on the sphenopalatine ganglion level under ultrasound guidance. * Standard voltage PRF parameters: 45 V, 5 Hz frequency, 5 ms pulse width, 360 seconds duration, electrode temperature ≤42°C. * Supravoltage PRF parameters: Higher voltage than standard (e.g., 60-70 V), with same frequency, pulse width, and duration, maintaining temperature ≤42°C to avoid nerve damage.

NCT Number	NCT07500558
Lead Sponsor	Minia University
Conditions	Chronic Migraine, Headache
Enrollment	100 participants
Start Date	2026-03-31
Primary Completion	2027-03-22 (estimated)
Study Completion	2027-04-02 (estimated)
Updated on ClinicalTrials.gov	2026-06-16