Clinical Trial

Impact of Sequential Double Embryo Transfer on Live Birth Rates: A Case-Control Study.

Study acronym: SEQ-ET
Completed
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Summary
The main aim of this study is to evaluate the impact and identify potential indications for sequential double embryo transfer (SEQ-ET) in couples undergoing assisted reproductive technology (ART). The study will compare live birth rates (LBR) between patients receiving SEQ-ET and those receiving standard double embryo transfer (DET), while assessing safety outcomes and potential indications, including endometrial immune under-activation. Each SEQ-ET case will be matched with a DET control based on age, transfer attempt rank, and ART technique. We hypothesize that SEQ-ET may enhance implantation in couples with previous ART failures without increasing the risk of complications, potentially through localized maternal-endometrial immune communication initiated by the initially transferred cleavage-stage embryos.
Trial Details
NCT Number NCT07499453
Lead Sponsor Hopital Pierre Rouques - Les Bluets
Conditions Infertility
Enrollment 778 participants
Start Date 2014-01
Primary Completion 2023-12 (estimated)
Study Completion 2024-09 (estimated)
Updated on ClinicalTrials.gov 2026-03-30