Chicago Data-driven Opioid Use Disorder Screening, Engagement, Treatment and Planning System

This study, called the Chicago Data-driven Opioid use disorder Screening, Engagement, Treatment and Planning (C-DOSETaP) System, tests a new system of clinical care for patients with opioid use disorder (OUD) across a large health system. The main questions this study aims to answer are: 1. Does the C-DOSETaP System increase screening for patients with OUD; 2. Does the C-DOSETaP System improve continuity of health care for patients with OUD; 3. Does the C-DOSETaP System increase use of medications for opioid use disorder; and 4. Does the C-DOSETaP System reduce the number of opioid-related deaths in the neighborhoods served.

NCT Number	NCT07498322
Lead Sponsor	University of Illinois at Chicago Collaborators: National Institute on Drug Abuse (NIDA)
Conditions	Opiod Use Disorder
Enrollment	271,031 participants
Start Date	2026-06-01
Primary Completion	2028-12-31 (estimated)
Study Completion	2029-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-01