Long-term Prospective Study of Korean CADASIL Patients

K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia. The investigators will track symptoms, brain scans, memory tests, and gene information to understand disease progression in Koreans and identify better treatments. Participants will visit clinics regularly for check-ups and blood tests. This study aims to help improve care for CADASIL patients and families worldwide.

NCT Number	NCT07497867
Lead Sponsor	Jeju National University Hospital Collaborators: Asan Medical Center, Chonnam National University Hospital, Chungbuk National University Hospital, Dong-A University Hospital, Ewha Woman University Medical Center, Hallym University Medical Center, Hanyang University Seoul Hospital, Inje University Ilsan Paik Hospital, Kangdong Sacred Heart Hospital, Keimyung University Dongsan Medical Center, Korea University Ansan Hospital, Korea University Guro Hospital, Kyung Hee University Hospital, Kyungpook National University Hospital, Nowon Eulji Medical Center, Pusan National University Hospital, Seoul Medical Center, Seoul National University Bundang Hospital, Seoul National University Hospital, Severance Hospital, Soonchunhyang University Hospital, Ulsan University Hospital, Yeungnam University Hospital, Daejeon Eulji University Medical Center, Jeonbuk National University Hospital, DongGuk University
Conditions	CADASIL, Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy
Enrollment	500 participants
Start Date	2023-07-10
Primary Completion	2035-12-31 (estimated)
Study Completion	2040-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-14