GCF and Saliva Levels of IL-36α in Periodontal Disease

Interleukin-36 (IL-36), recently identified and members of the IL-1 family, have been reported to be important regulators of host defense against pathogens in the oral mucosa. The aim of this study was to investigate the levels of IL-36 alpha (α) in saliva and gingival crevicular fluid (GCF) of patients with periodontitis, gingivitis and periodontally healthy individuals and to compare these levels with clinical parameters.

NCT Number	NCT07497828
Lead Sponsor	Ordu University
Conditions	Periodontal Diseases, Saliva, Gingival Crevicular Fluid, Cytokine
Enrollment	80 participants
Start Date	2023-12-10
Primary Completion	2025-01-10 (estimated)
Study Completion	2025-01-10 (estimated)
Updated on ClinicalTrials.gov	2026-03-27