Clinical Trial

A Novel Multi-Modal Approach to Promote Functional Outcomes in Cognitively Frail Older Adults

Study acronym: TMS MRI TBS
Recruiting
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Summary
The goal of this clinical trial is to explore the effects of intermittent theta burst stimulation (iTBS) primed with theta burst stimulation (cTBS), on top of aerobic exercise, on cognitive function, mobility, and brain activity in older adults with cognitive frailty. Understanding these effects will help us develop intervention models that benefit cognitively frail older adults. The main questions it aims to answer are: 1. Does the combination of iTBS primed with cTBS and aerobic exercise lead to greater improvements in cognition and mobility in older adults with cognitive frailty compared to non-priming iTBS and sham stimulation? 2. What are the neural mechanisms responsible for the improvements in cognition and mobility associated with the combination of iTBS primed with cTBS and aerobic exercise in older adults with cognitive frailty?
Trial Details
NCT Number NCT07497334
Lead Sponsor The Hong Kong Polytechnic University
Conditions Frailty at Older Adults, Mild Cognitive Impairment
Enrollment 45 participants
Start Date 2025-01-05
Primary Completion 2027-06-30 (estimated)
Study Completion 2027-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-27