Effect of Oral Microbiota on MDRO Decolonization

Randomized, placebo-controlled trial to evaluate the safety and efficacy of oral intestinal microbiota capsules for decolonizing multidrug-resistant organisms (MDROs) and Clostridioides difficile in patients requiring prolonged antibiotic therapy. The primary outcome was clearance of pre-existing MDROs or C. difficile from stool 14 days post-intervention. Secondary outcomes included adverse events, hospitalization rates, and need for additional antibiotics during 30-day follow-up.

NCT Number	NCT07496502
Lead Sponsor	Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Collaborators: Consejo Nacional de Humanidades, Ciencias y Tecnologias (CONAHCYT)
Conditions	Clostridioides Difficile Infection, Drug Resistance, Bacterial, Gastrointestinal Microbiome, Multidrug-resistant Colonization, Microbiota
Enrollment	42 participants
Start Date	2022-03-31
Primary Completion	2022-06-14 (estimated)
Study Completion	2022-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-03-27