Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury

Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU). However, prolonged exposure to IMV is consistently associated with an increased risk of ventilator-related complications and adverse outcomes. Accordingly, alongside the initiation of IMV, timely and safe liberation from ventilator should be considered. Nevertheless, data detailing the weaning process and its associated outcomes in mechanically ventilated patients with ABI remain scarce. To address this gap, the investigators conducted an observational study aimed at characterizing the ventilator weaning process and outcomes in patients with ABI receiving IMV, using the modified WIND classification.

NCT Number	NCT07496125
Lead Sponsor	Southeast University, China
Conditions	Acute Brain Injuries, Mechanical Ventilation
Start Date	2018-01-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-03 (estimated)
Updated on ClinicalTrials.gov	2026-06-08