Inflammatory Markers in Lumbar Radicular Pain Treated With PRF and TFESI

This retrospective observational study aims to evaluate the predictive value of systemic inflammatory markers in determining treatment response in patients with lumbar radicular pain treated with a combination of pulsed radiofrequency (PRF) and transforaminal epidural steroid injection (TFESI). Hematologic indices derived from routine blood tests-including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-neutrophil ratio (PNR), neutrophil-to-monocyte ratio (NMR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), mean platelet volume (MPV), red cell distribution width-standard deviation (RDW-SD), and red cell distribution width-coefficient of variation (RDW-CV) and pain scores assessed using the Numeric Rating Scale (NRS), will be analyzed in relation to treatment success (defined as ≥50% NRS reduction at 4 weeks). Receiver operating characteristic (ROC) analysis will be used to determine optimal cutoff values for significant markers. The study aims to contribute to personalized pain management strategies by identifying accessible biomarkers that may predict treatment outcomes.

NCT Number	NCT07495566
Lead Sponsor	Ankara Etlik City Hospital
Conditions	Inflammatory Response, Radiculopathy, Radiculopathy Lumbar, Chronic Pain
Enrollment	264 participants
Start Date	2025-12-30
Primary Completion	2026-01-15 (estimated)
Study Completion	2026-02-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-30