Effects of Microbiological and Immunological Factors on the Lower Urinary Tract

Millions of patients of all ages suffer worldwide from diverse urinary pathologies, such as lower urinary tract (LUT) dysfunction, bladder pain syndrome, urinary tract infections (UTIs), or bladder cancer. The research project investigates the interplay between the bladder and the microbiome. The goal is to evaluate the association of microbiological and immunological factors with lower urinary tract health in humans.

NCT Number	NCT07494864
Lead Sponsor	University of Zurich Collaborators: Kessler Group, Rätsch Group, Slack Group, Boyman Group, Sunagawa Group, Zamboni Group, Loessner Group, McKinney Group, Nexus, Research Group Dirk Bumann, Research Group Christoph Dehio
Conditions	Asymptomatic Bacteriuria in Subjects Not Requiring Assisted Bladder Emptying, Asymptomatic Bacteriuria in Subjects Relying on Some Type of Catheter, Recurrent Non-catheter Associated UTIs, Acute Catheter-associated UTI (CAUTI), Recurrent Catheter-associated UTI (CAUTI), Chronic Pelvic Pain, Non-neurogenic Overactive Bladder Syndrome / LUT Symptoms, Non-muscle-invasive Bladder Cancer
Enrollment	800 participants
Start Date	2023-06-01
Primary Completion	2026-11-30 (estimated)
Study Completion	2026-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-03-27