Sphenopalatine Ganglion Block for Post-Dural Puncture Headache

This pilot randomised controlled trial compared sphenopalatine ganglion block (SPGB) using intranasal 2% lidocaine versus conservative management (bed rest and aggressive hydration) in patients who developed post-dural puncture headache (PDPH) following accidental dural puncture with 17G Tuohy needles during epidural procedures. The primary outcomes were feasibility metrics (recruitment, retention, and protocol adherence). Secondary outcomes included pain intensity measured by the Numerical Rating Scale (NRS 0-10) at 30 minutes, 12 hours, and 24 hours post-intervention; rescue analgesia requirements; mobilisation time; and adverse events.

NCT Number	NCT07494383
Lead Sponsor	ISSSTE Hospital Regional "Gral. Ignacio Zaragoza"
Conditions	Post-Dural Puncture Headache, Headache
Enrollment	26 participants
Start Date	2024-05-29
Primary Completion	2024-06-24 (estimated)
Study Completion	2024-06-28 (estimated)
Updated on ClinicalTrials.gov	2026-05-15