Clinical Trial

Extended Oral Tranexamic Acid After Primary Total Knee Arthroplasty

Not Yet Recruiting
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Summary
This study is a prospective double-blind randomized controlled trial to evaluate the effect of extended oral TXA after primary total TKA on short-term and mid-term postoperative outcomes, including function, pain, and postoperative complications over a 24-month period, with evaluations at 6 weeks, 3 months, 12 months, and 24 months. Each group of 175 patients will receive either extended oral TXA 1.95g daily or placebo for 7 days postoperatively. Function will be assessed by Knee Injury and Osteoarthritis Outcome Score, Joint Replacement (KOOS, JR) scores measured at all post operative time points as well as range of motion (ROM) (measured at all visits).
Trial Details
NCT Number NCT07494032
Lead Sponsor NYU Langone Health
Conditions Knee Arthropathy
Enrollment 350 participants
Start Date 2026-05-01
Primary Completion 2029-05-01 (estimated)
Study Completion 2029-05-01 (estimated)
Updated on ClinicalTrials.gov 2026-03-27