Clinical Trial

Enhanced Recovery After Surgery (ERAS) in Patients With Peritoneal Carcinomatosis Undergoing Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Study acronym: EPICH
Recruiting
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Record status
This record was last updated April 3, 2026 (before its estimated July 1, 2026 completion). Its status may not reflect the trial's current state.
Summary
This prospective multicenter interventional pre-post study aims to evaluate the effect of implementing an Enhanced Recovery After Surgery (ERAS) protocol in patients with peritoneal carcinomatosis undergoing cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC). Approximately 300 patients will be enrolled across 20 Italian centers. During an initial pre-intervention period, usual perioperative management will be described; during a subsequent intervention period, participating centers will apply a predefined ERAS protocol. The primary objective is to assess the effect of ERAS implementation on mean postoperative hospital length of stay.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2026-03-20.
Trial Details
NCT Number NCT07493876
Lead Sponsor Fondazione del Piemonte per l'Oncologia
Conditions Peritoneal Carcinomatosis
Enrollment 300 participants
Start Date 2025-01-23
Primary Completion 2026-07-01 (estimated)
Study Completion 2027-12-30 (estimated)
Updated on ClinicalTrials.gov 2026-04-03