Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy

The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.

NCT Number	NCT07492979
Lead Sponsor	Rigshospitalet, Denmark
Conditions	Cardiac Resynchronisation Therapy (CRT), Heart Failure, Conduction System Pacing
Enrollment	1,100 participants
Start Date	2026-06-17
Primary Completion	2031-03-01 (estimated)
Study Completion	2031-07-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-28