APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)

The goal of this clinical trial is to determine whether antibiotics improve recovery from acute uncomplicated diverticulitis (AUD) in racially and ethnically diverse United States clinical practice. The main questions it seeks to answer are: * What is the feasibility for completing a subsequent definitive efficacy trial of antibiotics vs. placebo to treat AUD? * What are the needs for successful recruitment of racial and ethnic subgroups? * What are the effects of a placebo compared to antibiotics for AUD on a range of key patient-centric efficacy and safety endpoints? * How do such effects differ by race and ethnicity? Researchers will compare a placebo to antibiotics to see if AUD can be treated without using antibiotics. Participants will: * Take two antibiotics or a matching placebo every day for 10 days * Receive analgesia, gastric protection, diet modifications, and a follow-up * Submit daily photos of pills to the study team to verify adherence

NCT Number	NCT07492134
Lead Sponsor	Vanderbilt University Medical Center Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Acute Uncomplicated Diverticulitis
Enrollment	100 participants
Start Date	2026-07-07
Primary Completion	2028-04-01 (estimated)
Study Completion	2028-10-01 (estimated)
Updated on ClinicalTrials.gov	2026-07-08