Validation of the Use of the Arteriovenous Tension Difference in CO2 Under Hyperbaric Conditions

The central venous-arterial carbon dioxide tension difference is used daily in intensive care to establish peripheral tissue hypoperfusion, mainly mediated by a low cardiac index. The partial pressures of gases (oxygen, carbon dioxide) increase in the blood of patients breathing 100% oxygen in hyperbaric conditions. Thus, the validity of this biomarker in situations of acute circulatory failure during a hyperbaric oxygen therapy session has not been established. The objective of the study is therefore to establish the diagnostic performance of the central venous-arterial carbon dioxide tension difference in the diagnosis of a low cardiac index in patients with septic shock undergoing hyperbaric oxygen therapy for necrotizing fasciitis.

NCT Number	NCT07492030
Lead Sponsor	University Hospital, Lille Collaborators: Santelys Association, HyperbaricCare
Conditions	Necrotizing Fascitis, Cellulitis, Septic Shock
Enrollment	74 participants
Start Date	2026-06-15
Primary Completion	2027-09-15 (estimated)
Study Completion	2028-03-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-14