Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D

Periodontal disease is a chronic inflammatory condition associated with systemic diseases, highlighting the concept of periodontal medicine. This study aims to investigate the relationship between periodontal inflammation, oral lesions, and hepatitis B+D infection, with or without bulevirtide treatment. Oral-periodontal clinical parameters and targeted inflammatory biomarkers in saliva and gingival crevicular fluid will be evaluated in three groups: patients with hepatitis B+D receiving bulevirtide, patients with hepatitis B+D not receiving bulevirtide, and healthy controls.

NCT Number	NCT07491848
Lead Sponsor	Research Center of Periodontal-Systemic Interactions Collaborators: University of Medicine and Pharmacy Craiova, Spitalul clinic judetean de urgenta Craiova
Conditions	HEPATITIS B CHRONIC, Hepatitis D, Periodontitis
Enrollment	25 participants
Start Date	2026-02-15
Primary Completion	2027-02-15 (estimated)
Study Completion	2027-02-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-25