Multimodal Ultrasound for Differentiating Lymphedema and Lipedema

The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema. Differentiating these two chronic conditions based solely on clinical examination can be challenging due to overlapping symptoms. This study will utilize various non-invasive ultrasound techniques-including B-mode ultrasound, strain elastography, power Doppler, and quantitative ImageJ analysis-to compare tissue characteristics among patients with lymphedema, patients with lipedema, and healthy controls. The goal is to identify reliable, non-invasive imaging biomarkers that can facilitate early and accurate diagnosis, thereby optimizing patient management.

NCT Number	NCT07489248
Lead Sponsor	Kayseri City Hospital
Conditions	Lymphedema, Lipedema
Enrollment	75 participants
Start Date	2026-03-19
Primary Completion	2026-08-01 (estimated)
Study Completion	2026-09-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-24