MODELING OBSESSIVE COMPULSIVE DISORDER AND EXPLORING TREATMENT RESPONSE USING INNOVATIVE THERAPIES AND STEM CELLS

This study focuses on people with obsessive-compulsive disorder (OCD) who do not respond well to standard treatments. Researchers aim to understand why some patients respond to medications or brain stimulation therapies, while others do not. The study will include 60 patients grouped by their treatment response: 1. Those who respond to medications 2. Those who respond to transcranial magnetic stimulation (TMS) 3. Those who do not respond to either Blood samples will be used to create nerve cells in the lab, allowing scientists to study how these cells react to treatments and brain stimulation. By combining clinical information with lab findings, the goal is to discover biological markers that predict which therapy will work best for each person. This research hopes to improve personalized treatment options for OCD.

NCT Number	NCT07488663
Lead Sponsor	ASST Fatebenefratelli Sacco Collaborators: Fondazione IRCCS San Gerardo dei Tintori, Istittuo ricerca carattere Sceintifico Fatenefratelli Brescia
Conditions	Obsessive - Compulsive Disorder
Enrollment	60 participants
Start Date	2023-04-30
Primary Completion	2027-01 (estimated)
Study Completion	2027-04-29 (estimated)
Updated on ClinicalTrials.gov	2026-03-23