The Effect of Proton Pump Inhibitors(PPIs) on Endoscopic Treatment of Walled-off Necrosis (WON)

In this multicenter, randomized controlled trial, patients with pancreatic walled-off necrosis (WON) based on inclusion and exclusion criteria will be randomly assigned in a 1:1 ratio to either receive intravenous infusion or oral administration of continuous proton pump inhibitors (PPIs) or to undergo no PPI (nPPI) therapy after endoscopic ultrasound-guided transluminal drainage/debridement. Clinical data and patient-reported outcomes will be systematically collected at baseline and during follow-up periods. The study aims to assess whether PPI use after EUS-TD (Endoscopic Ultrasonography-Guided Transmural Drainage) increases the number of direct endoscopic necrosectomies required to managing WON. Additionally, the study will investigate the impact of PPI use on the incidence of stent occlusion and postoperative complications following EUS-TD, as well as its effect on the average duration of hospitalization and associated costs for patients with WON.

NCT Number	NCT07488299
Lead Sponsor	Qilu Hospital of Shandong University Collaborators: 960th Hospital of Joint Logistics Support Force of People's Liberation Army of China, Shandong Provincial Hospital, Shengli Oilfield Hospital, Shenzhen People's Hospital, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Nanfang Hospital, Southern Medical University
Conditions	Pancreatic Walled-off Necrosis
Enrollment	120 participants
Start Date	2025-09-17
Primary Completion	2028-03-20 (estimated)
Study Completion	2028-03-20 (estimated)
Updated on ClinicalTrials.gov	2026-08-10