Multi Disciplinary Sickle Cell Disease Obstetrics Care Program in Ghana

The goal of this observational study is to determine the feasibility and effectiveness of initiating a multidisciplinary sickle cell disease (SCD) obstetrics program for women with SCD in a non-academic hospital. The main question it aims to answer is: In a before-and-after study design, we will test the hypothesis that multidisciplinary care for pregnant women with SCD in a non-academic hospital will result in a 50% relative risk reduction in mortality compared to the mortality rate in pregnant women with SCD in the same hospital before the multidisciplinary care. Participants will be managed using the academic hospital's multidisciplinary sickle cell disease obstetrics protocol adapted for the non-academic hospital

NCT Number	NCT07488091
Lead Sponsor	University of Ghana Medical School Collaborators: Vanderbilt University Medical Center, Fogarty International Center of the National Institute of Health
Conditions	Sickle Cell Disease and Pregnancy
Enrollment	198 participants
Start Date	2026-01-22
Primary Completion	2028-01-15 (estimated)
Study Completion	2028-03-15 (estimated)
Updated on ClinicalTrials.gov	2026-03-23