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The Impact of Salt Intake on Sodium in the Skin and Inflammatory Skin Disease

Study acronym: SIS-ISD
StatusRecruiting
PhasePhase 4
Started2026-07-14
View on ClinicalTrials.gov ↗

Amendment history

2026-09-08
notable
Study Status, Contacts/Locations v2
Recruitment opened
Start dateestimated 2026-06-22→confirmed 2026-07-14
Study sitesdetails revised at 2 of 2 sites
Collaboratorsdetails revised at 1 of 1 entry
2026-06-05
minor
Study Status, Outcome Measures v1
Start date2026-03-16→2026-06-22
2026-03-17
minor
Original filing
The goal of this clinical trial is to demonstrate the feasibility of a trial that examines the impact of changes in dietary sodium intake on skin sodium levels, atopic dermatitis, and psoriasis. In addition, it aims to generate preliminary data to begin to answer the following questions: 1. Is there an association between skin sodium concentration and atopic dermatitis and psoriasis severity? 2. Are changes in dietary sodium are associated with changes in skin sodium concentration and atopic dermatitis and psoriasis severity? Researchers will compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake. Participants will: * Follow a low-salt diet for the duration of the 13-week study * Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa * Visit the clinic up to 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI
Trial Details
NCT Number NCT07487831
Lead Sponsor University of California, San Francisco
Collaborators: LEO Foundation
Conditions Atopic Dermatitis (Eczema), Psoriasis
Enrollment 50 participants
Start Date 2026-07-14
Primary Completion 2028-03-17 (estimated)
Study Completion 2028-03-17 (estimated)
Updated on ClinicalTrials.gov 2026-09-09