Clinical Trial

Functionally Enhanced ALPP-Targeted Engineered T Cells in Advanced Solid Tumors

Recruiting Early Phase 1
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Summary
This is a single-arm, open-label, dose-escalation clinical trial designed to evaluate the safety, tolerability, expansion, and persistence of functionally enhanced ALPP-targeted engineered T Cells (Herein referred to as Enhanced ALPP CAR-T) in patients with ALPP-positive recurrent or metastatic solid tumors who have progressed after prior therapies. The primary objective is to determine the maximum tolerated dose (MTD), with a secondary aim to assess preliminary clinical efficacy in solid tumors.
Trial Details
NCT Number NCT07487597
Lead Sponsor TCRCure Biopharma Ltd.
Conditions Solid Tumor
Enrollment 24 participants
Start Date 2026-02-28
Primary Completion 2028-02-28 (estimated)
Study Completion 2029-02-28 (estimated)
Updated on ClinicalTrials.gov 2026-03-23